Further studies on the metabolic control of conidiation of N.crassa

Metabolic control of conidiatio

The clustering and bias of radio-selected AGN and star-forming galaxies in the COSMOS field

Dark matter haloes in which galaxies reside are likely to have a significant impact on their evolution. We investigate the link between dark matter haloes and their constituent galaxies by measuring the angular two-point correlation function of radio sources, using recently released 3 GHz imaging over $\sim 2 \ \mathrm{deg}^2$of the COSMOS field. We split the radio source population into Star Forming Galaxies (SFGs) and Active Galactic Nuclei (AGN), and further separate the AGN into radiatively efficient and inefficient accreters. Restricting our analysis to$z<1$, we find SFGs have a bias,$b = 1.5 ^{+0.1}_{-0.2}$, at a median redshift of$z=0.62$. On the other hand, AGN are significantly more strongly clustered with$b = 2.1\pm 0.2$at a median redshift of 0.7. This supports the idea that AGN are hosted by more massive haloes than SFGs. We also find low-accretion rate AGN are more clustered ($b = 2.9 \pm 0.3$) than high-accretion rate AGN ($b = 1.8^{+0.4}_{-0.5}$) at the same redshift ($z \sim 0.7$), suggesting that low-accretion rate AGN reside in higher mass haloes. This supports previous evidence that the relatively hot gas that inhabits the most massive haloes is unable to be easily accreted by the central AGN, causing them to be inefficient. We also find evidence that low-accretion rate AGN appear to reside in halo masses of$M_{h} \sim 3-4 \times 10^{13}h^{-1}$M$_{\odot}$at all redshifts. On the other hand, the efficient accreters reside in haloes of$M_{h} \sim 1-2 \times 10^{13}h^{-1}$M$_{\odot}$at low redshift but can reside in relatively lower mass haloes at higher redshifts. This could be due to the increased prevalence of cold gas in lower mass haloes at$z \ge 1$compared to$z<1$.Comment: 20 pages, 10 figures, 1 table, accepted by MNRA

Neural Bases of Cognitive Impairments in Post-Traumatic Stress Disorders : A Mini-Review of Functional Magnetic Resonance Imaging Findings

Introduction: Post-Traumatic Stress Disorder (PTSD) is often associated with impairments in emotional and cognitive domains. Contrarily to the emotional sphere, neural basis underpinnings to cognitive impairments are still not well known. Methods: We performed a bibliographic search on PUBMED of all the studies investigating the cognitive impairments in PTSD individuals. We considered only studies that applied cognitive tasks using a functional Magnetic Resonance Imaging technique. The inclusion criteria were met by nine studies. Results: Overall, PTSD individuals reported significant impairments in the dorsolateral prefrontal cortex, anterior cingulate cortex, inferior frontal gyrus, insula, inferior temporal cortex, supplement motor area, and Default Mode Network (DMN). Moreover, abnormal activity was reported in subcortical structures (e.g. hippocampus, amygdala, thalamus) and in the cerebellum. Limitations: Cognitive functioning was assessed using different cognitive tasks. Potential confounding factors such as age, sex, symptoms intensity, and comorbidities might have influenced the results. Conclusion: So far, the evidence reported that PTSD is characterized by cognitive impairments in several domains, such as attention, memory and autonomic arousal, which may be due to selective dysfunctions in brain regions that are part of cortical networks, the limbic system and DMN. However, further studies are needed in order to better assess the role of cognitive impairments in PTSD and to develop more targeted therapeutic approaches

Sodium fraction excretion rate in nocturnal enuresis correlates with nocturnal polyuria and osmolality

Abstract: Purpose: We verify the sodium fraction excretion rate (FE Na) and potassium fraction excretion WE K) rates in monosymptomatic nocturnal enuresis. We also correlate FE Na and FE K to urinary osmolality, nocturnal polyuria and vasopressin in the same population. Materials and Methods: A total of 438 children 6 to 15 years old (mean age 9.7) presenting with monosymptomatic nocturnal enuresis were recruited from different centers. Inclusion criteria were 3 or greater wet nights a week, no daytime incontinence and no treatment in the previous 2 months. Exclusion criteria were cardiopathy, endocrinopathy, psychiatric problems and urinary tract abnormalities. Micturition chart, diurnal (8 am to 8 pm) and nocturnal (8 pm to 8 am) urine collection, including separate diuresis volumes, (Na, K and Ca) electrolytes and osmolality were evaluated, as well as serum electrolytes, creatinine and nocturnal (4 am) vasopressin. Diurnal and nocturnal FE K and FE Na were calculated. ANOVA test, chi-square test, Student's t test and Pearson correlation test were used for statistical analysis. Results: Nocturnal polyuria (diurnal to nocturnal diuresis ratio less than 1) was found in 273 children (62.3%, group I and nocturnal urine volumes were normal in 165 with enuresis (37.7%, group 2). Nocturnal FE Na was abnormal in 179 children (40.8%), including 118 in group 1 (43.2%) and 61 in group 2 (36.9%) (chi-square not significant). FE Na was also increased in nocturnal versus daytime diuresis (Student's t test p < 0.001). In group 1 nocturnal FE Na correlated with nocturnal diuresis (Pearson correlation p = 0.003, r = +0.175), while daytime FE Na and nocturnal FE Na correlated with diurnal diuresis (Pearson correlation p = 0.001, r = +0.225 and Pearson correlation p = 0.001, r = +0.209, respectively). In group 2 nocturnal FE Na did not correlate with diuresis (Pearson correlation p = 0.103, r = +0.128) but correlated with vasopressin values (Pearson correlation p = 0.042, r = -0.205). Urine osmolality was reduced in 140 children (31.9%) and correlated with nocturnal diuresis (Pearson correlation p = 0.003, r = -0.321). Vasopressin was decreased in 332 children (75.8%, 62.6% in group 1 and 13.2% in group 2). No significant difference was found between sexes and age of enuretic subgroups. Conclusions: Nocturnal FE Na correlates with nocturnal diuresis, whereas daytime FE Na does not. FE K in daytime and nighttime diuresis does not statistically differ in nocturnal polyuric and nonpolyuric enuretic groups. Osmolality correlates with nocturnal diuresis, and vasopressin at 4 am was lower in the nocturnal polyuric group. The hypothesis of a subset of enuretic patients presenting with nocturnal polyuria associated with high nocturnal natriuria and low vasopressin values has been confirmed

The role and the effect of magnesium in mental disorders: A systematic review

Introduction: Magnesium is an essential cation involved in many functions within the central nervous system, including transmission and intracellular signal transduction. Several studies have shown its usefulness in neurological and psychiatric diseases. Furthermore, it seems that magnesium levels are lowered in the course of several mental disorders, especially depression. Objectives: In this study, we wish to evaluate the presence of a relationship between the levels of magnesium and the presence of psychiatric pathology as well as the effectiveness of magnesium as a therapeutic supplementation. Methods: A systematic search of scientific records concerning magnesium in psychiatric disorders published from 2010 up to March 2020 was performed. We collected a total of 32 articles: 18 on Depressive Disorders (DD), four on Anxiety Disorders (AD), four on Attention Deficit Hyperactivity Disorder (ADHD), three on Autism Spectrum Disorder (ASD), one on Obsessive\u2013Compulsive Disorder (OCD), one on Schizophrenia (SCZ) and one on Eating Disorders (ED). Results: Twelve studies highlighted mainly positive results in depressive symptoms. Seven showed a significant correlation between reduced plasma magnesium values and depression measured with psychometric scales. Two papers reported improved depressive symptoms after magnesium intake, two in association with antidepressants, compared to controls. No significant association between magnesium serum levels and panic or Generalized Anxiety Disorder (GAD) patients, in two distinct papers, was found. In two other papers, a reduced Hamilton Anxiety Rating Scale (HAM-A) score in depressed patients correlated with higher levels of magnesium and beneficial levels of magnesium in stressed patients was found. Two papers reported low levels of magnesium in association with ADHD. Only one of three papers showed lower levels of magnesium in ASD. ED and SCZ reported a variation in magnesium levels in some aspects of the disease. Conclusion: The results are not univocal, both in terms of the plasma levels and of therapeutic effects. However, from the available evidence, it emerged that supplementation with magnesium could be beneficial. Therefore, it is necessary to design ad hoc clinical trials to evaluate the efficacy of magnesium alone or together with other drugs (antidepressants) in order to establish the correct use of this cation with potential therapeutic effects

English Reading Culture at the Hong Kong University of Science and Technology: Habits, Interests, and Attitudes of First-Year Undergraduate Students

The Hong Kong University of Science and Technology aims to further cultivate an English reading culture among its students. The goal of this project, sponsored by the Language Center, was to characterize the first-year undergraduate students’ English reading habits, interests, and attitudes. The findings of this study were used to compile a list of strategies to further enhance the English reading culture at the Hong Kong University of Science and Technology and to form recommendations for the Language Center

Olfactory and gustatory dysfunctions in SARS-CoV-2 infection

Among Coronavirus Disease 2019 (COVID-19) manifestations, Olfactory (OD) and Gustatory (GD) Dysfunctions (OGD) have drawn considerable attention, becoming a sort of hallmark of the disease. Many have speculated on the pathogenesis and clinical characteristics of these disturbances; however, no definite answers have been produced on the topic. With this systematic review, we aimed to collect all the available evidence regarding the prevalence of OGD, the timing of their onset and their resolution, their rate of recovery and their role as diagnostic and prognostic tools for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection

Body Mass Index in Children and Their Parents: A Cross-Sectional Study in a Study Population of Children from Southern Italy

The prevalence of overweight and obesity has increased over the last decades. Parental obesity plays an important role in determining childhood obesity. We aimed to evaluate the relationship between parental and offspring’ weight status in a population of children from South of Italy, as no data have ever been published from this area. We recruited 636 children (5.7 ± 1.5 years old) and their parents. Seventy-three (11.5%) and sixteen (2.5%) children were overweight and obese, respectively. Offspring weight status was significantly associated with parents’ weight status. The linear regression analysis showed that offspring BMI was more affected by paternal than by maternal BMI. Our data confirmed that parents’ weight status plays an important role on children’s BMI. Interestingly, in our study, parents’ height and weight were measured and not reported as in most of the previous papers, strengthening our conclusions. We suggest that intensive nutritional education and preventive programs should be performed in children with overweight / obese parents rather than in children with normal weight parent. Furthermore, nutritional education should be performed also for overweight parents to modify preventable risk factor for pediatric obesity